Synthesis and Antibacterial Evaluation of Ionic Liquids Derived of Triaminophenaziums and their Sulfur Analogues
Project acronym: ELISA
Topics: bacterial resistances, biomaterial, phenaziniums, ionic liquids
Disciplinary fields: chemistry, physics, microbiology, biochemistry
Summary: The world health organization raises alarm regularly about the emergence of new bacterial resistances to today’s antibiotics suggesting that action must be taken urgently to develop new antibacterial agents. In this context, two new classes of molecules have been recently developed by the project team. In one hand, new phosphonium ionic liquids particularly efficient against Staphylococcus aureus, a bacteria responsible for a large part of nosocomial infections and displaying fluorescent properties that could allow to understand their bacterial penetration mechanism. However, although these molecules can be used as biomaterial for surface treatment, they cannot be developed as in vivo antibiotic mainly because of their toxicity. On the other hand, the development was done for a versatile and particularly effective synthetic route to obtain the first triaminophenaziums for which it is possible to modulate the physico-chemical properties according to the aimed application. Theses phenaziniums can be viewed as a hybrid class of anticancer phenazines, quinolinium and related phenothiazines or clofazimines, known for their antimicrobial activities. ELISA aims to combine the two new classes of molecules recently developed by the project team.
Project duration: 04/01/2018 – 03/31/2021
Call for application: Interdisciplinarité 2016