In Vivo Metabolic and Ionic Imaging of Human Organs at 7T
Project acronym: IMETIONIC-7
Topics: magnetic resonance (MR), bioenergetics, human imaging
Disciplinary fields: health & life sciences, magnetic resonance exploration, medicine, biology
Summary: This project aims to develop and to validate in vivo non-invasive magnetic resonance (MR) methods assessing the coupling between energetics and ionic homeostasis within multiple human organs. Phosphorus energetics in all organs are indeed tightly linked to sodium homeostasis mediated by various ionic pumps, exchangers and channels. The proposal is to set up the methodological requirements to quantify phosphorylated metabolites (ATP, PCr) relative concentrations, intracellular pH and regulation of sodium concentrations within brain, spinal cord, skeletal muscle and heart. The innovative aspect of the proposal relies on the multi-organ approach. We will first develop in vivo Phosphorus (31P) MR spectroscopic imaging and sodium (23Na) MRI using the ultra-high field (UHF) 7T MRscanner equipping the CEMEREM (Equipex 7T-AMI), which will overcome the fundamental limitations of these methods thanks to increased signal to noise, spectral and spatial resolution compared to conventional 3T systems. Various constraints are accounted for: spatial resolution, motion correction and susceptibility artifacts. We propose to address organ specific methodological challenges with tailored MR acquisitions.
Bioenergetics are key features of the living cells health. Deciphering such mechanisms in vivo and non-invasively will help to better understand numerous pathophysiological processes in both acute and chronic diseases. Following the methodological development phase, clinical questions relative to bioenergetic dysfunctions, will be addressed with collaborators involved in the project, about sclerosis, epilepsy, amyotrophic lateral sclerosis, myocardial infarction and cardiomyopathies.
Project duration: 04/01/2018 – 03/31/2021
Call for application: Emergence et Innovation 2016
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